Killingholme B Power Station, located in North Killingholme, North Lincolnshire, is a 900 MW combined-cycle gas turbine (CCGT) plant situated near the Lindsey Oil Refinery and adjacent to Killingholme A. Built by Powergen and opened in 1993, it was only the second gas-fired station constructed in the UK at the time. It is now owned and operated by Uniper (formerly E.ON UK).

The station uses two 450 MW Siemens V94.2 gas turbines, each connected to a heat recovery steam generator feeding a single steam turbine in a 2-into-1 configuration. Natural gas is supplied through a 26-mile pipeline from Theddlethorpe.

After being taken offline in 2002 due to low electricity prices, Killingholme B returned to service in 2005. The site also hosted an education centre run by E.ON UK to engage local schools and communities.