Little Barford Power Station is a combined cycle gas turbine power station in the village of Little Barford in Bedfordshire, England. It lies just south of the A428 St Neots bypass and east of the Wyboston Leisure Park. The River Great Ouse runs alongside. It was formerly the site of two coal-fired power stations, now demolished. The station is operated by RWE.

The net capacity of 727 MW is sufficient to supply over half a million households.

Construction of the gas-fired station started in 1994, and it opened in 1996. The company that built it, Swindon-based National Power, became Innogy in August 2000. That company was bought by the German electricity company, Essen-based RWE in March 2002, and became RWE npower. The station is now owned and operated by RWE Generation UK.