Staythorpe C Power Station is a 1,735 MWe gas-fired power station at Staythorpe between Southwell and Newark-on-Trent in Nottinghamshire, England, between the River Trent and Nottingham to Lincoln railway line. The station was handed over to the owner RWE Generation UK from Alstom Power with full commercial operation being achieved in December 2010. The official opening ceremony attended by Charles Hendry, Minister of State took place on 9 May 2011.

The £680 million plant is owned by the German energy company, RWE Generation UK. It is the second largest gas-fired power station in the UK and the third largest in Europe, by generating capacity, as of 2021. It has an overall efficiency in excess of 58%.

Staythorpe C was built on the site of two former CEGB coal-fired power stations, the 360 MW Staythorpe A and the 360 MW Staythorpe B.